buprenorphine transdermal and pentobarbital each raise sedation. Stay clear of or Use Alternate Drug. Restrict use to people for whom substitute therapy possibilities are inadequate
pentobarbital will reduce the extent or effect of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lower the extent or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Solid CYP3A4 inducers might lessen suvorexant efficacy; if elevated suvorexant dose essential, will not exceed twenty mg/working day
pentobarbital will reduce the level or influence of zaleplon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
pentobarbital will lessen the extent or influence of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Minimal/Importance Not known.
pentobarbital will reduce the extent or influence of buspirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will boost the level or impact of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Nembutal Use Alternate Drug. Coadministration of ivosidenib with sturdy CYP3A4 inducers lessened ivosidenib plasma concentrations.
pentobarbital will lessen the extent or influence of aripiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will decrease the extent or result of alprazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
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pentobarbital will lessen the extent or result of sufentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital improves amounts of vortioxetine by increasing metabolism. Modify Therapy/Check Closely. Take into consideration escalating the vortioxetine dose when coadministered with strong CYP inducers for >fourteen times; to not exceed three periods primary vortioxetine dose.
pentobarbital will minimize the extent or effect of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; avoid use in sufferers who are chronically making use of a robust CYP3A4 inducer
Contraindicated (1)pentobarbital will decrease the extent or outcome of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with potent CYP3A4 inducers isn't recommended